Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment
Paper Link: https://www.mdpi.com/2218-1989/14/1/73
*Call to action* – HELP US promote this line of research by COPYING THE ABOVE LINK and including it in a post to social media, especially Twitter.
Dr. Nicholas Norwitz is a 25-year-old Ivy League Valedictorian who obtained his PhD in ketogenic nutrition and metabolism from Oxford University and is currently pursuing his MD at Harvard Medical School.
0:00 – Intro
0:28 – Metabolic Demonstration
0:43 – Part I, The Ddea
1:30 – LMHR Triad
1:58 – Lipid Energy Model
3:06 – Part II, The Experimental Design
4:19 – Part III, Results
6:00 – Results Summary
6:40 – Part IV, What’s Next?
7:37 – Thanks and Call to Action
Aim: To tested the prediction — consistent with the Lipid Energy Model (below) — that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy.
Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject.
The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It’s a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as ‘productive provocation,’ a form of ‘legit-bait’ that will hopefully help prompt discussions and larger-scale experiments that need to happen.
6 select Prior publications
1/ META of RCTs (new, 1/16/24) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009 *LINK: https://www.sciencedirect.com/science… VIDEO: • NEW STUDY Proves it’s BMI not Butter …
2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768 LINK: https://www.frontiersin.org/articles/… VIDEO: • LDL cholesterol in Healthy Women on Keto
3/ JCL editorial Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010 Link: https://www.lipidjournal.com/article/…
4/ Lipid Energy Model Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460 Link: https://pubmed.ncbi.nlm.nih.gov/35629… Video: • High LDL Cholesterol Increases on a L…
5/ LMHR, first paper Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144 Link: https://cdn.nutrition.org/article/S24…
6/ Low Sat Fat LMHR case report Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325 Link: https://www.ncbi.nlm.nih.gov/pmc/arti… Video: • New Case Study – High LDL Cholesterol…